p270

風にまかせてうまい機会の到来を逃さない

RNA Polymerase IIがヌクレオソームからDNAを外すのではなく，ゆらぎに身をまかせて読めるところを読んでいくらしいのはこの例である．

PolyII rectifies nucleosomal fluctuations

9 Hodges Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II

S 325 626 

*An optical tweezers assay to follow individual Pol II complexes as they transcribe nucleosomal DNA. 

*The nucleosome behaves as a fluctuating barrier that locally increases pause density, slows pause recovery, and reduces the apparent pause-free velocity of Pol II. 

*The polymerase, rather than actively separating DNA from histones, functions instead as a ratchet that rectifies nucleosomal fluctuations.